Amplixin Review: A Better Topical Solution for Hormonal Hair Loss?

Amplixin Review: A Better Topical Solution for Hormonal Hair Loss?

This post was most recently updated on June 11th, 2023

Male/Female Pattern Baldness knows no age. According to the American Hair Loss Association, two-thirds of American men experience some form of MPB by age 35, and women show signs of FPB by age 50. Fortunately, topical solutions may help you resolve this issue. Amplixin Hair Serum has gained popularity on Amazon due to its assured results to lessen hair loss. Thus, our Amplixin review will investigate their products that cater to your hair loss.

Amplixin hair serum is a gold standard for preventing hair loss progression and stimulating healthy hair growth. Below, we cover everything you need to know about its benefits, key ingredients, real-life user reviews, possible side effects, and more.

picture of amplixin intensive growth serum - amplixin review

What is Amplixin?

Once hair loss starts, pretty sure you want something that will work fast without false hope. Amplixin, which has received 3,446+ global ratings on Amazon (and still counting), is formulated with natural ingredients as opposed to harmful chemicals found in numerous hair care products in the market.

All Amplixin products are manufactured in the USA using fully researched ingredients, including a special DHT-blocking blend, biotin, argan oil, coconut oil, and more. Plus, Amplixin is free of sulfate, paraben, preservatives, and allergen which may be safe on all hair types. It is also cruelty-free and BPA-free.

Today, Amplixin Hair Support System is available in 6 versions for hair-loss supporting treatment, such as:

In this article, we are going to dig deeper into Amplixin Intensive Biotin Serum (it’s by far the #1 product) which promises to prevent hair loss and promote new hair growth.

Amplixin Hair Growth Serum Review


For: Men and women of all hair types, hair textures, ages, and ethnicities.

Best Use: Those with hair loss due to excessive DHT levels (a hormonal imbalance), otherwise known as Androgenic Alopecia or Male/Female Pattern Baldness.

Benefits: Hair growth serum proven to help slow down the rate of excessive shedding and encourage healthy hair regrowth.

Key Ingredients: Red Clover, Bio-Mimetic Peptides, Caffeine, Biotin, Aloe Vera, Chamomile Extract, Sage Leaf, and Argan Oil.

If you’re looking for an effective topical solution to cater to your hair loss but are on a budget, Amplixin is worth trying. The formula is similar to a lightweight hair mousse, which doesn’t make your hair greasy. Amplixin has a fresh, herby scent, and it quickly fades. If you’re sensitive to fragrance, this serum should not bother you.

Who is it for?

Generally speaking, Amplixin hair growth serum works for both women and men of all hair types, from normal to thinning hair. This topical solution is also color-safe as Amplixin is crafted to avoid high levels of cleansing agents that can strip your hair color.

Formulated with AMPLIGRO® Complex, a clinically-studied blend of DHT-blocking ingredients, Amplixin Intensive Biotin Serum works best for people with:

  • androgenic alopecia (MPB and FPB),
  • receding hairline,
  • thinning at temples and crowns,
  • widening parts, and
  • bald spots.
Visualization of alopecia

Moreover, given Amplixin harnesses the power of Biotin, this serum is also suitable for women who experience after-pregnancy hair loss and those who notice stunted hair growth. According to multiple reports of users, Amplixin is also shown to do a great job on hair loss due to menopause, post-partum, stress, and over-processed damage.

How does it work?

The special ingredients behind Amplixin Intensive Biotin Serum lie in its AMPLIGRO® Complex. This patented ingredient blend consists of an abundance of scientifically backed DHT-blockers and antioxidants, such as Caffeine, Saw Palmetto, Bio-Mimetic Peptides, Jojoba, and Red Clover.

While Amplixin is applied to the scalp, the formula directly targets the key factor of your hair loss, particularly DHT levels. AMPLIGRO® Complex plays the biggest role in helping block the activity of alpha-5 reductase, an enzyme that is responsible to convert testosterone into dihydrotestosterone (DHT).

An illustration of the miniaturization of hair follicles due to DHT

Our hair follicles are very sensitive to this hormone, which is why the excessive level of DHT can shrink them out and cause them to weaken over time. Eventually, this leads our hair follicles to separate from our heads faster than new follicles regenerate. Blocking the production of DHT will eventually stimulate hair regrowth and even prevent excessive hair shedding.

Check out our article to learn how to reduce DHT levels naturally.

diagram of clinical trial results

An independent test has been conducted to prove the effectiveness of the ingredient blends. Results showed that AMPLIGRO® Complex improves hair growth by 13% and reduces hair fallout by up to 29% compared to the placebo group.

How to use it?

No matter how Amplixin works, one thing’s for certain: It can deliver great benefits if used properly. Additionally, Amplixin should be safe for everyone, but pregnant and nursing women may need to consult with a doctor first. Below are the Amplixin hair growth serum instructions:

  1. Spray the serum onto your scalp and hair on clean, damp/dry hair.
  2. Gently massage it into the scalp by moving your fingers in circles.
  3. Amplixin is a leave-in serum, so don’t wash out your hair right after applying. This serum can also be used together with other hair-loss treatments, both leave-in or wash-out.
  4. It is recommended to apply the serum minimum of 3 times a week for about 2 months. If you continue using the serum for 3-6 months, you can achieve the best results.

Even so, many users notice favorable improvements in hair loss reduction and better hair quality in less time. However, if you’re unhappy with the reliability of the product, Amplixin offers a 60-day money-back guarantee, which shows their confidence in the product.

How much does it cost?

Currently, Amplixin Intensive Biotin Serum’s price sits at $24.95 per 2 fl oz (60 mL) on Amazon. It is definitely not a cheap product, but not an expensive one either. Compared to hair growth serums like Vegamour and Folliboost, it’s actually more affordable.

amplixin review - picture of amplixin intensive biotin serum

In addition, it’s not a secret anymore that hair care treatment usually works best if you take the products in tandem. You can purchase a bundle of Amplixin Hair Growth Support System on Amazon for $64.95, which consists of a shampoo, conditioner, and serum.

amplixin review - picture of a bundle of amplixin shampoo, conditioner, and serum

Before making a purchase, let’s take a closer at the ingredients of Amplixin to better understand its benefits for your hair.

What’s Inside? (Ingredients Breakdown)

To find out the benefits of Amplixin Intensive Biotin Serum, let’s check its ingredients and how they work individually.


Most of the ingredients inside this special blend are DHT-blockers. Now let’s take a look at them one by one.

Red Clover

Besides men, androgenic alopecia also occurs in women who experience dramatic hormonal shifts, such as menopause. DHT levels in menopausal women usually happen due to a specific endocrine health condition like PCOS, which then can lead to hair follicles shrinking and hair loss.

This flowering plant contains a high level of isoflavones, a type of phytoestrogen, which are similar to estrogen. Due to its ability to act as estrogen, red clover can help mitigate hair loss and thinning hair issues due to perimenopause or menopause.

Bio-Mimetic Peptides (Acetyl Tetrapeptide-3)

Exclusively synthesized peptides that mimic naturally occurring peptides, acetyl tetrapeptide-3 is used in Amplixin. Although this mouthful ingredient is relatively new, acetyl tetrapeptide-3 has been shown to help combat androgenic alopecia.

A 2013 study suggests that a blend of Red Clover and Acetyl Tetrapeptide-3 has a synergistic action to combat hair loss and promote hair growth after 4 months of topical use. This duo works by inhibiting the DHT-causing 5-a-reductase enzyme and reducing micro-inflammation around hair follicles.


We love coffee. So many of us start the day with caffeine. But, did you know that caffeine is also found in topically applied hair care products, including Amplixin?

Unfortunately, there are a lot of assumptions that too much caffeine intake could lead to hair loss. However, there’s no solid evidence to show a direct connection between caffeine and hair loss.

But one thing we do know is that caffeine has been clinically proven to combat androgenic alopecia in both women and men. Caffeine is shown to increase anagen (hair-growth phase) duration, which then leads to the stimulating of hair growth.

Saw Palmetto

If you google “saw palmetto,” you’ll come across hair supplements that feature saw palmetto. Today, there are a lot of saw palmetto-contained supplements, for instance, Hair La Vie and Nutrafol. However, saw palmetto is also available as a liquid extract in many leave-in and wash-out treatments, including Amplixin.

One of the myriad benefits of saw palmetto is preventing the body from converting testosterone into DHT, which eventually leads to prevent hair loss. It also has anti-inflammatory properties which are beneficial for reducing scalp-related issues.


Derived from the seeds of the Simmondsia Chinensis plant, chances are you’ll find jojoba oil in at least one of your hair care products. Besides being a hydrating agent, jojoba also has antifungal and antibacterial properties which can help to treat dandruff, itchy scalp, and dry scalp.

Jojoba also has a reputation as a hair growth motivator. However, one comparison study found that in terms of hair growth promotion, jojoba oil is less effective than minoxidil and peppermint oil. Thus, jojoba may not be effective for androgenic alopecia therapy. But, you still get the benefits of hair softness and strengthening.


Biotin can be used topically or taken orally as a dietary supplement. This vitamin is very popular due to its purported benefits to promote healthy hair, skin, and nails. When applied topically, vitamin B7 or biotin has positive effects in supporting hair growth, hair strengthening, and overall hair health.

Aloe Vera

We all know that this clear gel from the aloe stalk is powerful in terms of hydration. Aloe vera works best in both moisture locks and loads, meaning it can help lock in moisture while also attracting moisture from the air.

It also has anti-inflammatory properties, which can help soothe the inflamed scalp and treat dandruff.

Chamomile Extract

Extracted from daisy-like flowers of the Asteraceae plant family, chamomile is known to promote strong hair and prevent split ends. It is also believed to reduce hair loss and promote hair growth.

A 2018 study suggests that chamomile can inhibit the action of the 5αR to convert testosterone into DHT, which then may be potent to treat hair loss.

Sage Leaf

The scientific name of Sage is Salvia Officinalis. It has been used as a natural dye to darken grays due to its natural tannins. Surprisingly, sage is not only a secret hair dye. It contains an abundance of beta-sitosterol, which is beneficial to block the activity of 5-alpha reductase to produce DHT.

Moreover, sage is also beneficial to rejuvenate and strengthen hair follicles. This could be due to its ability to improve blood circulation to the scalp, maximizing the supply of nutrients and oxygen to the hair follicles.

Argan Oil

Many refer to it as “liquid gold” due to its purported benefits for health and beauty remedies. Argan oil has anti-inflammatory and antioxidant properties that are great to treat scalp-related issues, such as dandruff, psoriasis, and seborrheic dermatitis.

Thus, its benefit in promoting scalp health can lead to preventing hair loss and the promotion of hair growth. Its antioxidant properties are also helpful to protect hair against free radical damage.

Comfrey Extract

The main benefit of this herb is to relieve scalp inflammation, stop dandruff, and treat eczema. Comfrey is loaded with polyphenols that contain anti-inflammatory properties. Plus, the allantoin compound in comfrey may help reduce dryness and improve hair shine.

Other Ingredients

Glycerin – Often derived from cane sugar or soybeans, glycerin is a top-notch hydrating agent that attracts moisture from the environment to prevent hair from drying out.

EDTA – Stands for EthyleneDiamineTetraaceticAcid. It’s a chelating agent that binds metal ions (coming from water) in the formula and makes them harmless when applied to the hair.

Xanthan Gum – A natural thickener and emulsion stabilizer that is produced from sugar molecules. It helps make a too-runny product more gel-like or a bit sticky.

Butylene Glycol – Acts as a solvent that helps the formula to absorb deeper and faster into the scalp. It is also beneficial to attract moisture into your hair to prevent dryness (humectant).

Dextran – Naturally produced from sugar beets via fermentation, dextran has water-binding properties which help to make the formula easy to apply on your hair and scalp.

EthylHexylGlycerin – A less-toxic, natural preservative that comes from soybean or palm as an alternative for parabens and sulfates. The benefit of Ethylhexylglycerin is to prevent the growth of bacteria and mold in the formula.

Phenoxyethanol –  A natural preservative that is naturally derived from green tea or synthesized in labs. Phenoxyethanol is less irritating and has a mild scent rather than parabens.

Fragrance – A perfuming ingredient that gives the product a pleasant smell. Those who are sensitive to fragrances may experience allergic dermatitis, so doing a patch test is a necessary step to prevent this issue.

To conclude, Amplixin is not only beneficial to promote hair growth and reduce hair loss but also helps to protect against damage, treat flaky scalp/dandruff, and overall hair health. Amplixin marketed itself as “preservative-free” meaning that they don’t contain any “harmful” preservatives. Amplixin still contains natural preservatives because, without them, the products would last mere days.

Now let’s take a look at real-life user experiences.

Results After Using Amplixin (Before and After Pictures)

Here are the results of Amplixin Intensive Biotin Serum from verified users with various hair types, hair lengths, hair concerns, hair colors, ages, and ethnicities.

Amplixin Review - 1

Results of a Caucasian male who has a large bald spot and thinning hair. The right picture shows significantly new hair regrowth on his bald spot.

Amplixin Review - 2

Results of a woman with Afro-American hair and a large thinning hair area. After one month of use, new hair regrowth started filling in that thinning area.

Amplixin Review - 3

Results of a brunette woman who has a large patch of hair due to stress. After diligently using the serum every day, the patch is no longer visible and her hair becomes fuller.

Amplixin Review - 4

Results of a brunette woman who has thinning hair on the crown. After using Amplixin for a few weeks, her hair feels thicker and looks healthier.

Amplixin Review - 5

Results of a woman who has Afro-American hair and receding hairline. After using Amplixin for a few weeks, the bald spot looks fuller with new hair and the hair feels softer.

Amplixin Review - 6

Results of a brunette woman with straight hair and a balding spot on her temple. After using the serum for 3 weeks, her hair grew much fuller, thicker, and stronger.

Amplixin Review - 7

Results of a woman who experienced no hair loss but using Amplixin to grow out a buzzcut. After only 10 months of use, the serum has doubled the length and the hair started to look fuller.

Amplixin Review - 8

Results of a 24-year-old woman who experienced hereditary thinning hair. After using Amplixin serum and shampoo for a month, her hair looks fuller, especially on the temple.

Now we know that Amplixin works for multiple users with different hair concerns and hair types. In the next section, we cover the possible side effects of Amplixin.

Amplixin Side Effects and Disadvantages

Most of the Amplixin ingredients are plant sourced, be it from flower pollens, leaves, seeds, etc. However, being natural doesn’t always mean it’s safe and free of adverse effects. Thus, this section rounded up possible side effects that may occur while using Amplixin hair growth serum.

Butylene glycol causes reactions on very sensitive skin

Butylene glycol is a water-soluble organic alcohol that is derived from petroleum. Just because it’s from petroleum, doesn’t always mean it’s unsafe to use. One study shows that the occurrence of allergic contact is low, although still a possibility.

If you have very sensitive skin or scalp, you may develop an irritation or an itchy rash. Discontinue the product and consult a dermatologist.

It’s not really preservative-free

Let’s be realistic: Preservatives are added to cosmetic products to keep it stays sterile. These substances are beneficial to prevent the growth of mold, fungi, bacteria, and yeast in the serums, which gives them a longer shelf life.

Preservative-free product (as Amplixin claims) is one that doesn’t contain any harmful preservatives. Amplixin still uses natural preservatives, such as EthylHexylGlycerin and Phenoxyethanol.

However, like Phenoxyethanol, side effects can still occur, even though it’s natural and less toxic. If your scalp is already sensitive to eczema or phenoxyethanol, you should steer clear of this substance.

Xanthan Gum may be a potential allergen

Xanthan gum is made when a polysaccharide sugar is fermented by the Xanthomonas campestris bacteria that are derived from corn, wheat, soy, or dairy. If you’re allergic to these sources, you should do a patch test to avoid irritation or consult a doctor first.

Keep away from eye and mouth contact

Acetyl Hexapeptide-8 is one of the key ingredients of Amplixin, meaning the concentration could be high enough. There are no adequate records of the side effects on the skin, but it may cause serious eye irritations.

Most importantly, it’s harmful if swallowed, so make sure to always wash your hands after applying Amplixin to your scalp and hair.

May cause hormone imbalance in pregnant and nursing mother

Red clover and saw palmetto might act like estrogen which then may cause hormone imbalances during pregnancy and breastfeeding. It is recommended to consult a doctor before using Amplixin Intensive Biotin Serum.

These are the possible side effects of Amplixin that may occur to those with certain conditions. Now, let’s take a look at the alternatives to Amplixin.

Alternatives to Amplixin Hair Growth Serum

Given below are three alternatives of Amplixin Intensive Biotin Serum you can find on Amazon. These hair growth serums are offered by Folliboost, Elevate, and Meraz Pureauty.

Tricho Labs Folliboost Hair Growth Serum

Folliboost Hair Growth Serum
Current Price: $39.95 for 2 fl oz

Rating: 3.9 out of 5 stars from 2,295+ global ratings

Key Ingredients: Anagain™, Baicapil™, Biotin, Arginine HCL, D-Panthenol, and Peppermint Oil

Folliboost is formulated with clinically proven ingredients that work by waking up dormant hair follicles. Even though this serum is specially designed for women, many men can also use it and notice improvement. Folliboost contains no DHT blockers, but it does contain peppermint oil that has been shown to work as effectively as minoxidil (an androgenic alopecia remedy).

When it comes to pricing, Folliboost is more expensive than Amplixin. Read our full review of Folliboost to learn more about the product.

Elevate Hair Growth Oil

Elevate Hair Growth Oil
Current Price: $18.95 (46% off) for 1 fl oz

Rating: 4.4 out of 5 stars from 6,983+ global ratings

Key Ingredients: Biotin, Minoxidil, and Ginseng Extract

If you’re looking for a leave-in treatment that is packed with an FDA-approved ingredient, Elevate can be the right choice. Formulated with 5% minoxidil, this serum is clinically proven for treating androgenic alopecia. Elevate works by delivering proper nutrients to your scalp, which then encourages hair follicles to produce new hair.

The normal price of Elevate is $34.95, which is a bit cheaper than Folliboost, but it’s still pricier compared to Amplixin.

Meraz Pureauty Biotin Hair Serum Advanced Formula

Meraz Pureauty Biotin Hair Serum Advanced Formula
Current Price: $19.49 (30% off) for 2 fl oz

Rating: 4 out of 5 stars from 1,643+ global ratings

Key Ingredients: Biotin, Pea Sprout Extract, Pro-Vitamin B5, Amino Acids, and Arginine HCl

Packed with lots of superstar ingredients, Meraz Pureauty works similarly to Folliboost, waking up the sleeping hair follicles. However, this serum is not formulated with DHT blockers. Besides male/female pattern baldness, this serum may be effective to treat hair loss due to over-processed damage, stress, and telogen effluvium.

At a normal price, you can get this serum for $27.99, which is not too expensive like Folliboost and Elevate.

Check our 18 best hair serums article to find more alternatives to Amplixin hair growth serum.

Final Verdict – Does Amplixin really work?

Based on reviews we sampled online, many users are delighted with the reliability of the product. Amplixin is crafted with many DHT-blocking ingredients, which makes it great to treat Male/Female Pattern Baldness or any hair loss due to hormonal imbalance.

There are also multiple reports that Amplixin works on them with different causes of hair loss, including stress and external damage. Unfortunately, Amplixin is not for everyone since some people reported that they didn’t see any improvement after using Amplixin.

Check out Amplixin hair serum here to see the benefits for yourself. If you have any questions or thoughts, tell us in the comment section below.

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